Na+/H+ exchanger NHE3 (apical epithelial Na+/H+ exchanger, solute carrier family 9 isoform A3, SLC9A3)

Function

• role in pH regulation
• elimination of acids generated by active metabolism or adverse environmental conditions
• major proton extruding system driven by the inward Na+ chemical gradient
• role in signal transduction
• binds SLC9A3R1 & SLC9A3R2
• interacts with SHANK2
• phosphorylated by PKA, which inhibits activity

Structure

• belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Compartment

membrane

More general terms

• transmembrane 10 protein
• solute carrier family 9 (SLC9, SLC9A)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6550
• OMIM: https://mirror.omim.org/entry/182307
• UniProt: http://www.uniprot.org/uniprot/P48764.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6550