beta-2 adrenergic receptor; beta-2 adrenoreceptor; beta-2 adrenoceptor (ADRB2, ADRB2R, B2AR)
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Function
- beta-adrenergic receptor
- binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
- binds SLC9A3R1 & GPRASP1
- palmitoylated; may reduce accessibility of Ser-345 & Ser- 346 by anchoring Cys-341 to the plasma membrane
- agonist stimulation promotes depalmitoylation & further allows Ser-345 & Ser-346 phosphorylation
- phosphorylated by PKA & BARK upon agonist stimulation, which mediates homologous desensitization of the receptor
- PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
cell membrane; multi-pass membrane protein
Pathology
- polymorphic forms of ADRB2 could impart some form of nocturnal asthma
- polymorphisms (C & G) alleles associated with different mortality when treated with beta-blocker after acute coronary syndrome
More general terms
Additional terms
References
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 748
- ↑ Principles of Neural Science, 3rd ed. Kandel ER, Schwartz JH & Jessell TM (eds), Elsevier NY 1991, pg 175
- ↑ Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, Spertus JA. Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA. 2005 Sep 28;294(12):1526-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16189366
- ↑ UniProt http://www.uniprot.org/uniprot/P07550.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRB2
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/adrb2/