G-protein coupled receptor-associated sorting protein 1; GASP-1 (GPRASP1, GASP, KIAA0443)

Function

• lysosomal sorting & down-regulation of G-protein coupled receptors
• targets G-protein coupled receptors for degradation in lysosomes
• interacts with cytoplasmic tails of G-protein coupled receptors:
  • dopamine D2 receptor
  • dopamine D4 receptor
  • delta opioid receptor
  • beta-2 adrenergic receptor
• interacts with PER1

Structure

belongs to the GPRASP family

Compartment

cytoplasm

Expression

• expressed in brain > medulla, spinal cord, substantia nigra

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9737
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9737
• OMIM: https://mirror.omim.org/entry/300417
• UniProt: http://www.uniprot.org/uniprot/Q5JY77.html