P2Y1 purinoceptor; P2Y purinoceptor 1; P2Y1; G-protein coupled purinergic receptor P2Y1 (P2RY1)

Function

• receptor for extracellular adenine nucleotides including ATP & ADP
• in platelets, binding to ADP leads to mobilization of intracellular Ca+2 via activation of phospholipase C, a change in platelet shape, & probably to platelet aggregation

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P & A2P5P; these inhibit Ca+2 mobilization & shape change in platelets

More general terms

• P2Y purinoceptor or P2Y purinergic receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5028
• OMIM: https://mirror.omim.org/entry/601167
• UniProt: http://www.uniprot.org/uniprot/P47900.html