supervillin (archvillin, p205/p250, SVIL)

Function

• forms high-affinity link between actin cytoskeleton & plasma membrane.
• isoform 2 (archvillin) is among the first costameric proteins to assemble during myogenesis; it contributes to myogenic membrane structure & differentiation
• binds to F-actin

Structure

• belongs to the villin/gelsolin family
• contains 5 gelsolin-like repeats
• contains 1 HP domain (headpiece domain)

Compartment

• cell membrane, cytoplasmic side
• tightly associated with both actin filaments & plasma membrane

Alternative splicing

named isoforms=2

Expression

• expressed in many tissues
• most abundant in muscle, bone marrow, thyroid, & salivary gland
• isoform 2 (archvillin) is muscle specific

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/604126
• UniProt: http://www.uniprot.org/uniprot/O95425.html