zyxin (zyxin-2)

Function

• adhesion plaque protein
• binds alpha-actinin & the CRP protein
• mediates adhesion-stimulated changes in gene expression (putative)
• interacts, via the Pro-rich regions, with EVH1 domains of ENAH & VASP, important for targeting to focal adhesions & formation of actin-rich structures

Structure

• contains 3 LIM zinc-binding domains

Compartment

• cytoplasm, cytoskeleton
• associates with the actin cytoskeleton near adhesion plaques

Pathology

• interacts with HPV type 6 protein E6
• does not interact significantly with E6 proteins from HPV types 11, 16, or 18

More general terms

• cytoskeletal adhesion protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602002
• UniProt: http://www.uniprot.org/uniprot/Q15942.html