protein ajuba (AJUBA, JUB)

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Function

component of cellular adhesives complexes
contributes to cell fate determination & regulates cell proliferation & differentiation
regulation of actin cytoskeleton dynamics & cell migration
role in linking &/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton
role in signal transduction from cell adhesion sites to the nucleus
role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment
component of the IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing the assembly & activity of PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex
can function as adapter molecule in formation of large multiprotein complexes that form on DNA & that influence transcription
interacts with AURKA/Aurora-A during mitosis & both proteins are phosphorylated as they form a complex.
interacts with CTNNA1/alpha-catenin & with F-actin
interacts with LATS2 during mitosis & this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome
interacts with GRB2 & PI51A (putative)
forms a complex with SQSTM1, PRKCZ & TRAF6
interacts with GLT1 (putative)
phosphorylated by LATS2 during mitosis
phosphorylated by AURKA

LIM region interacts with CTNNA1
preLIM region binds directly actin filaments
LIM-2 & LIM-3 domains mediate the interaction with the N-terminal region of AURKA
association between LATS2 & JUB requires 2nd LIM domain of JUB
belongs to the zyxin/ajuba family
contains 3 LIM Zn+2-binding domains

cytoplasm, cell membrane, cell junction, nucleus, centrosome
shuttles between the cytoplasm & the nucleus
localizes on centrosomes during G2-M phase
preferentially co-localizes with cadherin-adhesive complexes at sites of cell-cell contacts

'Ajuba' means 'curiosity' in Urdu, an Indian dialect