serine/threonine protein kinase LATS2; large tumor suppressor homolog 2; serine/threonine protein kinase kpm; kinase phosphorylated during mitosis protein; Warts-like kinase (LATS2, KPM)

Function

• negative regulator of YAP1 in the Hippo signaling pathway
• phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus
• tumor suppressor involved in:
  • centrosome duplication
  • maintenance of mitotic fidelity
  • genomic stability
• negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity
• negative regulator of the androgen receptor
• autophosphorylated & phosphorylated during M-phase & the G1/S-phase of the cell cycle
• phosphorylated & activated by STK3/MST2
• interacts with & is phosphorylated by AURKA.
• interacts with JUB during mitosis & this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome
• interacts (via PPxY motif) with YAP1 (via WW domains)
• interacts with MOBKL1A & MOBKL1B

Cofactor: Mg+2

Compartment

• co-localizes with STK6 at the centrosomes during interphase, early prophase & cytokinesis
• migrates to the spindle poles during mitosis, & to the midbody during cytokinesis

Expression

• expressed at high levels in heart & skeletal muscle

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26524
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26524
• OMIM: https://mirror.omim.org/entry/604861
• UniProt: http://www.uniprot.org/uniprot/Q9NRM7.html