Mps one binder kinase activator-like 1A; MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B (MOB1B, MOB4A, MOBKL1A)

Function

• activator of LATS1/2 in the Hippo signaling pathway
• stimulates the kinase activity of STK38L
• phosphorylated by STK3/MST2 & STK4/MST1 & this
• phosphorylation enhances its binding to LATS1
• binds STK38L
• interacts with LATS1 & LATS2

Structure

belongs to the MOB1/phocein family

Compartment

cytoplasm. nucleus

Expression

• expressed in adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain & fetal liver

More general terms

• Mps one binder kinase activator-like
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=92597
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:92597
• OMIM: https://mirror.omim.org/entry/609282
• UniProt: http://www.uniprot.org/uniprot/Q7L9L4.html