serine/threonine protein kinase 38-like; NDR2 protein kinase; nuclear Dbf2-related kinase 2 (STK38L, KIAA0965 NDR2)

Function

• role in regulation of structural processes in both differentiating & mature neurons (putative)
• activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP binding & autophosphorylation of Ser-282
• Thr-442 then undergoes Ca+2-dependent phosphorylation by STK24/MST3
• interactions between phosphorylated Thr-442 & the N-lobe promote additional structural changes that complete activation
• autoinhibition is also released by binding of MOB1/MOBKL1A & MOB2/HCCA2 to the N-terminal of STK38L
• phosphorylated upon DNA damage, probably by ATM or ATR
• homodimeric S100B binds two molecules of STK38L
• interacts with MOB1 & MOB2

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Compartment

• cytoplasm, cytoskeleton, membrane
• associated with the actin cytoskeleton
• colocalizes with STK24/MST3 in the membrane

Expression

• ubiquitously expressed
• highest expression in thymus

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23012
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23012
• UniProt: http://www.uniprot.org/uniprot/Q9Y2H1.html