serine/threonine protein kinase 24; mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3; contains: serine/threonine protein kinase 24 36kDa subunit MST3/N, serine/threonine protein kinase 24 12kDa subunit MST3/C (STK24, MST3)

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Function

serine/threonine protein kinase
phosphorylateds both Ser & Thr
promotes apoptosis in response to stress stimuli & caspase activation
mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8-MAPK9), JUN & p38 (MAPK11, MAPK12, MAPK13 & MAPK14) during oxidative stress
role in a staurosporine-induced caspase-independent apoptosis by regulating the nuclear translocation of AIFM1 & ENDOG & the DNAse activity associated with ENDOG
phosphorylates STK38L on Thr-442 & stimulates its kinase activity
regulates cellular migration with alteration of PTPN12 activity & PXN phosphorylation:
- phosphorylates PTPN12 & inhibits its activity
- may regulate PXN phosphorylation through PTPN12
may act as a key regulator of axon regeneration in the optic nerve & radial nerve
proteolytically processed by caspases during apoptosis
proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) & induction of apoptosis
isoform B is activated by phosphorylation by PKA
oxidative stress induces phosphorylation
activated by autophosphorylation at Thr-190
- Thr-190 phosphorylation is essential for function
Mn+2, Mg+2 & cobalt-dependent autophosphorylation is mainly on Thr
Zn+2-dependent autophosphorylation is on both Ser & Thr

monomer
belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
contains 1 protein kinase domain

isoform A is ubiquitous
isoform B is expressed in brain
- high expression in hippocampus & cerebral cortex