apoptosis-inducing factor 1, mitochondrial; programmed cell death protein 8 (AIFM1, AIF, PDCD8)
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Function
- probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death
- AIF is normally in mitochondria, translocates to the nucleus during apoptosis & induces mitochondria to release cytochrome C & caspase 9
- Bcl-2 inhibits mitochondrial release of AIF but otherwise does not affect apoptotis activity
- recombinant AIF causes chromatin condensation & DNA fragmentation in isolated nuclei
- binds to DNA in (sequence-independent)
- effects of AIF are independent of caspases[3]
- AIF is essential for programmed cell death during early morphogenesis, ie. cavitation of embryoid bodies
- interacts with XIAP
Structure
- belongs to the FAD-dependent oxidoreductase family
Compartment
- mitochondria intermembrane space
- nucleus
- translocated to the nucleus upon induction of apoptosis
Alternative splicing
- named isoforms=3
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O95831.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/AIFM1ID44053chXq25.html
- ↑ 3.0 3.1 Susin SA et al Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-7 1999 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9989411
- ↑ Joza N et al Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410:549-54, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11279485
- ↑ Daugas E et al Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 14:729, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10744629
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51060
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9131
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51060
- OMIM: https://mirror.omim.org/entry/300169
- UniProt: http://www.uniprot.org/uniprot/O95831.html