endonuclease G (ENDOG)

Function

• double-stranded DNA & single-stranded DNA endonuclease activity.
• able to generate RNA primers required by DNA polymerase gamma for initiating replication of mitochondrial DNA
• in addition to deoxyribonuclease activities, also has ribonuclease (Rnase) & Rnase H activities

Cofactor: Mn+2 or Mg+2

Structure

• homodimer (putative)
• belongs to the DNA/RNA non-specific endonuclease family
• active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules (putative)

Compartment

mitochondria

More general terms

• endodeoxyribonuclease
• endoribonuclease
• mitochondrial protein
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2021
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2021
• OMIM: https://mirror.omim.org/entry/600440
• UniProt: http://www.uniprot.org/uniprot/Q14249.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?