serine/threonine protein kinase LATS1; large tumor suppressor homolog 1; WARTS protein kinase; h-warts (LATS1, WARTS)

Function

• tumor suppressor involved in maintenance of ploidy via
  • mitotic progression
  • G1 tetraploidy checkpoint.
• negatively regulates G2/M transition; down-regulates CDC2 kinase activity
• regulates actin polymerization; negative modulation of LIMK1
• complexes with CDC2 in early mitosis
• binds phosphorylated ZYX, locazing to the mitotic spindle

Compartment

• localizes to the centrosomes throughout interphase
• migrates to the mitotic spindle during mitosis

More general terms

• serine/threonine kinase

Database

• OMIM: https://mirror.omim.org/entry/603473
• UniProt: http://www.uniprot.org/uniprot/O95835.html