hepatocyte growth factor-like protein; macrophage stimulatory protein; macrophage-stimulating protein; MSP; contains: hepatocyte growth factor-like protein alpha chain; hepatocyte growth factor-like protein beta chain (MST1, D3F15S2, DNF15S2, HGFL)

Function

• probably has no proteolytic activity, since crucial characteristicS of serine proteases catalytic sites are not conserved
• may be cleaved after Arg-483, to yield two chains held together by disulfide bonds, or two separate polypeptides
• dimer of an alpha chain & a beta chain linked by a disulfide bond

Structure

• belongs to the peptidase S1 family, plasminogen subfamily
• contains 4 kringle domains
• contains 1 PAN domain
• contains 1 peptidase S1 domain

Compartment

secreted

More general terms

• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4485
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4485
• OMIM: https://mirror.omim.org/entry/142408
• UniProt: http://www.uniprot.org/uniprot/P26927.html