Mps one binder kinase activator-like 1B; MOB kinase activator 1A; Mob1 alpha; Mob1A; Mob1 homolog 1B (MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B)

Function

• activator of LATS1/2 in the Hippo signaling pathway
• stimulates the kinase activity of STK38 & STK38L
• acts cooperatively with STK3/MST2 to activate STK38
• phosphorylated by STK3/MST2 & STK4/MST1
  • phosphorylation enhances its binding to LATS1
• binds STK38 & STK38L
• interacts with LATS1 & LATS2
• forms a tripartite complex with STK38 & STK3/MST2

Structure

belongs to the MOB1/phocein family

Alternative splicing

named isoforms=2

Expression

• adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid, heart, spinal cord, fetal brain & fetal liver

More general terms

• Mps one binder kinase activator-like
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55233
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55233
• OMIM: https://mirror.omim.org/entry/609281
• UniProt: http://www.uniprot.org/uniprot/Q9H8S9.html