sequestosome-1; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kD; ubiquitin-binding protein p62; EBI3-associated protein of 60 kD; p60; EBIAP (SQSTM1, ORCA, OSIL)

From Aaushi
Jump to navigation Jump to search

Function

Structure

Compartment

Expression

Pathology

More general terms

References

  1. 1.0 1.1 UniProt http://www.uniprot.org/uniprot/Q13501.html
  2. Pankiv S et al p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy J. Biol. Chem. 2007, 282:24131-2414 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17580304
  3. Ichimura Y Selective turnover of p62/A170/SQSTM1 by autophagy Autophagy. 2008 Nov 16;4(8):1063-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18776737
  4. 4.0 4.1 Komatsu M et al Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice Cell 2007, 131:1149-1163 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18083104
  5. Mathew R et al Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137(6):1062-75 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19524509
    Moscat J et al p62 at the Crossroads of Autophagy, Apoptosis, and Cancer Cell 2009, 137:1001-1004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19524504

Database