26S proteasome regulatory subunit S5A (26S proteasome non-ATPase regulatory subunit 4, Rpn10, multiubiquitin chain binding protein, antisecretory factor-1, AF, ASF, PSMD4, MCB1)

Function

• binds & presumably selects ubiquitin-conjugates for destruction
• displays selectivity for longer polyubiquitin chains
• modulates intestinal fluid secretion
• directly interacts with NUB1
• interacts with SQSTM1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way
• belongs to the proteasome subunit S5A family
• contains 2 UIM (ubiquitin-interacting motif) repeats
• contains 1 VWFA domain

Alternative splicing

named isoforms=2

More general terms

• 26S proteasome subunit
• phosphoprotein

Component of

• 19S proteasome (PA700 complex)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5710
• OMIM: https://mirror.omim.org/entry/601648
• UniProt: http://www.uniprot.org/uniprot/P55036.html