full=voltage-gated K+ channel subunit beta-1; K+ channel subunit beta-1; Kv-beta-1 (KCNAB1, KCNA1B)

Function

• accessory K+ channel protein which modulates activity of the pore-forming alpha subunit
• all three isoforms alter the functional properties of Kv1.4 & Kv1.5
• isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1
• forms heteromultimeric complex with alpha subunits interacts with SQSTM1 (putative)

Structure

• alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (probable)
• belongs to the shaker K+ channel beta subunit family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=3

Expression

• in brain, expressed in caudate nucleus, hippocampus & thalamus > amygdala & subthalamic nucleus
• expressed in both healthy & cardiomyopathic heart; up to four times more abundant in left ventricle than left atrium

More general terms

• voltage-gated K+ channel beta subunit

Additional terms

• voltage-gated K+ channel

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7881
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7881
• OMIM: https://mirror.omim.org/entry/601141
• UniProt: http://www.uniprot.org/uniprot/Q14722.html