K+ voltage-gated channel subfamily A member 2; voltage-gated K+ channel subunit Kv1.2; HBK5; NGK1; HUKIV (KCNA2, RBK2, RCK5, MK2)

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
• heterotetramer of K+ channel proteins
• binds PDZ domains of DLG1, DLG2 & DLG4 (putative)

Structure

• N-terminus may be important in determining the rate of inactivation of the channel
• the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• segment S4 is probably the voltage-sensor; it is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, A (Shaker) subfamily

Compartment

membrane

More general terms

• voltage-gated K+ channel alpha subunit
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P16389.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3737
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3737
• OMIM: https://mirror.omim.org/entry/176262