interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein (EBI3, IL27B)

Function

• cytokine that drives rapid clonal expansion of naive but not memory CD4+ T-cells
• synergizes with IL-12 to trigger IFN-gamma production of naive CD4+ T-cells (subunit of IL12 ?)
• signals through the cytokine receptor IL27RA
• interacts with SQSTM1

Structure

heterodimer of an alpha subunit & a beta subunit

Compartment

secreted

Expression

induction by EBV

More general terms

• interleukin

Component of

• interleukin-27 (IL-27)
• interleukin-12; cytotoxic lymphocyte maturation factor; NK cell stimulatory factor (IL12, IL-12)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10148
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10148
• OMIM: https://mirror.omim.org/entry/605816
• UniProt: http://www.uniprot.org/uniprot/Q14213.html