interleukin-27 receptor subunit alpha; IL-27R-alpha; WSX-1; type I T-cell cytokine receptor; TCCR; protein CRL1 (IL27RA, CRL1, TCCR, WSX1, UNQ296/PRO336)

Function

• ligand-binding subunit for IL27 receptor
• requires IL6ST (gp130) to mediate signal transduction in response to IL27
• acts through STAT3 & STAT1
• regulation of Th1-type immune response
• innate defense mechanisms

Structure

• WSXWS motif necessary for protein folding
• box 1 motif is required for JAK interaction
• belongs to the type I cytokine receptor family, type 2 subfamily
• contains 3 fibronectin F3 modules

Compartment

membrane

Expression

• expressed in lymphoid tissues, spleen, lymph nodes, peripheral blood leukocytes > heart, brain, fetal & adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney, colon
• in the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets
• weaker expression in CD19+ B-cells & monocytes

More general terms

• protein subunit
• glycoprotein

Additional terms

• interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein (EBI3, IL27B)

Component of

• interleukin-27 receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9466
• OMIM: https://mirror.omim.org/entry/605350
• UniProt: http://www.uniprot.org/uniprot/Q6UWB1.html