CD130; gp130; interleukin-6 receptor subunit beta; IL-6R-beta; interleukin-6 signal transducer; membrane glycoprotein 130; CDw130; oncostatin-M receptor alpha subunit (IL6ST)

Function

• signal-transducing molecule
• signal transducing subunit of several cytokine receptors
• receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 & BSF3 can utilize gp130 for initiating signal transduction
• binds to IL6/IL6R (alpha chain) complex, resulting in formation of high-affinity IL6 binding sites, & transduces the signal
• does not bind IL6
• may have a role in embryonic development (putative).
• forms heterodimers composed of LIPR & IL6ST (type 1 OSM receptor)
• also forms heterodimers composed of OSMR & IL6ST (type 2 OSM receptor)
• phosphorylation of Ser-782 down-regulates cell surface expression

Structure

• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type 1 cytokine receptor family, type 2 subfamily
• contains 5 fibronectin F3 modules
• contains 1 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• isoform 1: cell membrane
• isoform 2: secreted

Alternative splicing

named isoforms=2

Expression

• found in all the tissues & cell lines examined
• expression not restricted to IL6 responsive cells

Pathology

• isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA

Notes

• GP130 also maps to 130 kD leucine-rich protein

More general terms

• CD antigen
• glycoprotein
• protein subunit
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3572
• OMIM: https://mirror.omim.org/entry/600694
• UniProt: http://www.uniprot.org/uniprot/P40189.html