leukemia inhibitory factor; melanoma-derived LPL inhibitor; differentiation-stimulating factor; D factor,; HILDA; MLPLI; emfilermin (LIF)
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Function
- similar in it's activities to IL-6
- LIF has the capacity to induce terminal differentiation in leukemic cells
- activities include
- induction of hematopoietic differentiation in normal & myeloid leukemia cells
- induction of neuronal cell differentiation
- stimulation of acute-phase protein synthesis in hepatocytes
Structure
belongs to the LIF/OSM family
Compartment
Expression
induced by IL-1 in sympathetic ganglia Pharmacolology:
- in phase II clinical trial, ddeveloped by Amrad to assist embryo implantation in women who have failed to become pregnant despite assisted reproductive technologies
More general terms
References
- ↑ Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1542794
- ↑ Hopkins SJ & Rothwell NJ Cytokines and the nervous system. I: Expression and recognition. TINS 18:83 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7537419
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3976
- ↑ Wikipedia leukemia inhibitory factor entry http://en.wikipedia.org/wiki/Leukemia_inhibitory_factor
- ↑ UniProt http://www.uniprot.org/uniprot/P15018.html