cardiotrophin-like cytokine factor 1 (B cell-stimulating factor 3, BSF-3, novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1)

Function

• cytokine with B-cell stimulating capability
• binds to & activates the ILST/gp130 receptor
• component of CRLF1-CLCF1 complex

Compartment

secreted

Expression

• expressed in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, fetal liver

Pathology

• defects in CRLF1 result in cold-induced sweating syndrome 2 (CISS2)

More general terms

• secreted protein
• glycoprotein

Additional terms

• cold-induced sweating syndrome (CISS)

Component of

• CRLF1/CLCF1 complex

Database

• OMIM: https://mirror.omim.org/entry/607672
• UniProt: http://www.uniprot.org/uniprot/Q9UBD9.html