cytokine receptor-like factor 1 (cytokine-like factor 1, CLF-1, ZcytoR5, CRLF1, ZCYTOR5, UNQ288/PRO327)

Function

• cytokine receptor subunit
• regulatory role in the immune system
• fetal development, nervous system development (putative)
• forms covalently linked dimers & tetramers
• component of CRLF1-CLCF1 complex
• induced by IFN-gamma, TNF-alpha, IL-6 in fibrobasts
• WSXWS essential for folding, transport, receptor binding
• has 2 fibronectin F3 modules

Compartment

secreted

Expression

• expressed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid, ovary, fetal lung

Pathology

• defects in CRLF1 result in cold-induced sweating syndrome 1 (CISS1)

More general terms

• secreted protein
• glycoprotein

Additional terms

• cold-induced sweating syndrome (CISS)

Component of

• CRLF1/CLCF1 complex

Database

• OMIM: https://mirror.omim.org/entry/272430
• OMIM: https://mirror.omim.org/entry/604237
• UniProt: http://www.uniprot.org/uniprot/O75462.html