CD126; interleukin-6 receptor subunit alpha; IL-6R-alpha; IL-6R 1; membrane glycoprotein 80; gp80 (IL6R)

Function

• IL-6 receptor subunit
• binds to IL6 with low affinity, but does not transduce a signal
• signal activation requires association with gp130
• external domain of IL-6 receptor subunit interacts with a cell surface protein, gp130, that functions as a signal transducer
• soluble form may also be released from the membrane by proteolysis
• low concentration of a soluble form of IL6R acts as an agonist of IL6 activity
• soluble IL6R activates osteoclasts & thus provokes bone reabsorbtion

Structure

• the two fibronectin type-3-like domains, contained in the N-terminal part, form together a cytokine-binding domain
• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
• belongs to the type 1 cytokine receptor family, type 3 subfamily
• contains 1 fibronectin F3 module
• contains 1 Ig-like C2-type domains (immunoglobulin-like)

Compartment

• isoform 1: basolateral cell membrane
• isoform 2: secreted soluble IL6R may also be present in serum

Alternative splicing

named isoforms=2

Expression

• isoform 2 is expressed in peripheral blood mononuclear cells & weakly found in urine & serum

Pathology

• soluble IL6R may play a role in patients with multiple myeloma

More general terms

• hematopoietin receptor superfamily
• protein subunit
• CD antigen

Additional terms

• interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; hybridoma growth factor; interferon beta-2; IFN-beta-2 (IL6, IFNB2)

Component of

• interleukin-6 receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3570
• OMIM: https://mirror.omim.org/entry/147880
• UniProt: http://www.uniprot.org/uniprot/P08887.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3570