interleukin-6 receptor
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Function
- activation may lead to the regulation of the immune response, acute-phase reactions & hematopoiesis
Structure
- hexamer of two molecules each of IL6, IL6R & gp130
- external domain of IL6R interacts with gp130, that functions as a signal transducer
Polymorphism
- IL6 receptor gene SNP(s) associated with risk for aortic aneurysm
Pharmacology
- IL-6 receptor inhibitors sarilumab & tocilizumab indicated for treatment of rheumatoid arthritis
- sarilumab more effective than adalimumab (TNF-alpha inhibitor) as monotherapy forheumatoid arthritis[4]
- tocilizumab also used for treatment of giant cell arteritis
More general terms
Additional terms
- interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; hybridoma growth factor; interferon beta-2; IFN-beta-2 (IL6, IFNB2)
- sarilumab (Kevzara)
References
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ Itoh N, Yonehara S, Schreurs J, Gorman DM, Maruyama K, Ishii A, Yahara I, Arai K, Miyajima A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science. 1990 Jan 19;247(4940):324-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2404337
- ↑ Miyajima A, Hara T, Kitamura T. Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem Sci. 1992 Oct;17(10):378-82. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1455505
- ↑ 4.0 4.1 Burmester GR, Lin Y, Patel R et al Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial. Ann Rheum Dis. Nov 17, 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27856432 Free full text <Internet> http://ard.bmj.com/content/early/2016/11/16/annrheumdis-2016-210310.abstract
- ↑ Cai T, Zhang Y, Ho YL et al Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy. A Phenome-Wide Association Study. JAMA Cardiol. Published online August 8, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30090940 https://jamanetwork.com/journals/jamacardiology/fullarticle/2696438