interleukin-11; IL-11; adipogenesis inhibitory factor; AGIF; oprelvekin (IL11)

Function

• stimulates proliferation of hematopoietic stem cells & megakaryocyte progenitor cells
• induces megakaryocyte maturation resulting in increased platelet production

Structure

belongs to the IL-6 superfamily

Compartment

secreted

Pharmacology

• available as oprelvekin under the name Neumega (Wyeth)
• used for prevention of severe thrombocytopenia & the reducing the need for platelet transfusion following myelosuppressive chemotherapy

More general terms

• interleukin

More specific terms

• oprelvekin [IL-11] (Neumega)

Additional terms

• interleukin-11 receptor (IL11 receptor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3589
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3589
• OMIM: https://mirror.omim.org/entry/147681
• UniProt: http://www.uniprot.org/uniprot/P20809.html