interleukin-11 receptor alpha chain; IL-11R-alpha; IL-11RA (IL11RA)

Function

• ligand-binding subunit for interleukin-11 receptor
• on ligand binding, forms a multimer complex with IL6ST/gp130
• receptor systems for IL6, LIF, OSM, CNTF, IL11 & CT1 utilize IL6ST/gp130 for initiating signal transduction
• the IL11/IL11RA/IL6ST complex may be involved in the control of proliferation &/or differentiation of skeletogenic progenitor or other mesenchymal cells

Structure

• belongs to the type I cytokine receptor family, type 3 subfamily
• contains 2 fibronectin F3 modules
• contains 1 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• membrane
• may be soluble form

Alternative splicing

named isoforms=2

Expression

• expressed cell lines, including
  • myelogenous leukemia
  • megakaryocytic leukemia cell line Mo7E
  • erythroleukemia cell line TF1
  • osteosarcoma cell lines, MG-63, Saos-2.
• also expressed in normal & malignant prostate epithelial cell lines

Pathology

• increased levels of IL11R are found in prostate carcinoma

More general terms

• protein subunit
• membrane protein
• glycoprotein

Additional terms

• interleukin-11; IL-11; adipogenesis inhibitory factor; AGIF; oprelvekin (IL11)

Component of

• interleukin-11 receptor (IL11 receptor)
• IL11/IL11RA/IL6ST complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3590
• OMIM: https://mirror.omim.org/entry/600939
• UniProt: http://www.uniprot.org/uniprot/Q14626.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3590