Na+ & Cl- dependent creatine transporter 1 (creatine transporter 1, CT1, solute carrier family 6 member 8, SLC6A8)

Function

• required for the uptake of creatine in muscles & brain

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

membrane

Expression

• predominantly expressed in skeletal muscle & kidney
• also found in brain, heart, colon, testis & prostate

Pathology

• defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome

More general terms

• solute carrier family 6

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6535
• OMIM: https://mirror.omim.org/entry/300036
• OMIM: https://mirror.omim.org/entry/300352
• UniProt: http://www.uniprot.org/uniprot/P48029.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6535