creatine

Pharmacology

• derived primarily from meats, poultry, & seafood

Indications

• used as a sports supplement
• dietary creatine may lower risk for depression (RR=0.7)
  • protective association stronger in women (RR=0.62 than men RR=0.72)

Pharmacokinetics

• metabolized to creatinine Interactions:
• can increase serum creatinine

Laboratory

• creatine in amniotic fluid
• creatine in CSF
• creatine in serum/plasma
• creatine in urine
• creatine in vitreous fluid

Mechanism of action

• taken in the hope of increasing creatine phosphate

More general terms

• guanidine
• intermediary metabolite
• carboxylate

More specific terms

• creatine phosphate; phosphocreatine

Additional terms

• creatinine
• X-linked creatine deficiency syndrome

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=586
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=588
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=80116
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=134732