impaired glucose tolerance

Etiology

• artificial sweeteners can alter the gut microbiome leading to absorption of more calories & glucose intolerance

Epidemiology

• 25% of obese children
• 21% of obese adolescents

Laboratory

• fasting plasma glucose 110-126 mg/dL.
• two hour glucose on glucose tolerance testing 140-200 mg/dL

* case presentation with fasting plasma glucose of 94 mg/dL, HgbA1c of 6.1% & two hour glucose on glucose tolerance testing 177 mg/dL (no additional testing needed)

Management

• see prediabetes
• acarbose reduces the risk of diabetes
• metformin reduces the risk of diabetes

More general terms

• impaired glycemic control

Additional terms

• diabetes mellitus type 2 (insulin-resistant)
• glucose (dextrose, D-glucose)
• glucose challenge (tolerance) test
• insulin resistance