mitogen activated protein kinase kinase 5 (MAPK/ERK kinase 5, MEK5, MAP2K5, MKK5, PRKMK5)

Function

• may participate together with ERK5 in a growth factor stimulated signaling cascade
• specifically activates ERK5, but not other MAP kinases such as ERK2 or p38
• not phosphorylated by RAFA, RAFB or RAFC
• may interact with GTPases such as CDC42
• interacts with PARD6A & MAP3K3
• forms a complex with SQSTM1 & PRKCZ or PRKCI (putative)
• interacts with Yersinia yopJ
• activated by phosphorylation on Ser/Thr by MEK kinases (putative)
• Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation & activation, thus blocking the MAPK signaling pathway

ATP + a protein = ADP + a phosphoprotein

Structure

• OPR domain mediates interactions with SQSTM1, PARD6A & MAP3K3 (putative)
• belongs to the protein kinase superfamily, STE Ser/Thr
• protein kinase family, MAP kinase kinase subfamily
• contains 1 OPR domain
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• expressed in many adult tissues
• abundant in heart & skeletal muscle

More general terms

• MAP2K/MEK

Database

• UniProt: http://www.uniprot.org/uniprot/Q13163.html
• OMIM: https://mirror.omim.org/entry/602520
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5607