mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3, MEK kinase 3, MAP3K3, MAPK/ERK kinase kinase 3, MEKK3, MAPKKK3)

Function

• component of a protein kinase signal transduction cascade
• mediates activation of the NF-kappa-B, AP1 & DDIT3 transcriptional regulators
• binds both upstream activators & downstream substrates in multimolecular complexes
• part of a complex with MAP2K3, RAC1 & CCM2
• interacts with MAP2K5 & SPAG9
• activated by phosphorylation on Thr-530

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
• contains 1 OPR domain contains 1 protein kinase domain

More general terms

• MAP3K/MEKK

Database

• UniProt: http://www.uniprot.org/uniprot/Q99759.html
• OMIM: https://mirror.omim.org/entry/602539
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4215