catenin alpha-1; cadherin-associated protein; alpha E-catenin; NY-REN-13 antigen (CTNNA1)

Function

• associates with the cytoplasmic domain of a variety of cadherins
• may play a role in cell differentiation
• binds MLLT4 & F-actin (putative)
• interacts directly with PSEN1 & CTNNB1 to form part of the PSEN1/cadherin/catenin adhesion complex
• interacts with ARHGAP21 & with JUB
• sumoylated

Structure

belongs to the vinculin/alpha-catenin family

Compartment

• cytoplasm, cytoskeleton
• cell junction, adherens junction
• cell membrane, cytoplasmic side
• found at cell-cell boundaries & probably at cell-matrix boundaries

Alternative splicing

named isoforms=2

Expression

expressed ubiquitously in normal tissues

Pathology

• abnormalities of alpha-catenin are involved in the process of cancer invasion & metastasis

More general terms

• alpha catenin
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1495
• OMIM: https://mirror.omim.org/entry/116805
• UniProt: http://www.uniprot.org/uniprot/P35221.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1495