excitatory amino acid transporter 2; Na+ dependent glutamate/aspartate transporter 2; glutamate/aspartate transporter II; solute carrier family 1 member 2 (SLC1A2, EAAT2, GLT1)
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Function
- transports L-glutamate & also L- & D-aspartate
- may be astrocyte/glial glutamate/aspartate transporter in brain
- essential for terminating postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
- acts as a symporter by cotransporting Na+
- interacts with JUB (putative)
Structure
- homotrimer
- glycosylated
- belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family
Compartment
membrane
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P43004.html
- ↑ Kanai Y, Hediger MA. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 1992 Dec 3;360(6403):467-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1280334
- ↑ Kanai Y, Smith CP, Hediger MA. A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 1993 Dec;7(15):1450-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7903261