glutamate/aspartate transporter (excitatory amino acid transporter)
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Introduction
4 subtypes of glutamate/aspartate transporters have been defined by differences in sequence, pharmacology, tissue distribution, & channel-like properties:
GLAST1 & GLAST2 are astroglial transporters
GLAST3 & GLAST4 are selectively localized in neurons
Function
Expression
brain
More general terms
- amino acid transport protein
- solute carrier family 6
- phosphoprotein
- glycoprotein
- plasma membrane protein
More specific terms
- excitatory amino acid transporter 1; Na+ dependent glutamate/aspartate transporter 1; GLAST-1; solute carrier family 1 member 3 (SLC1A3, EAAT1, GLAST, GLAST1)
- excitatory amino acid transporter 2; Na+ dependent glutamate/aspartate transporter 2; glutamate/aspartate transporter II; solute carrier family 1 member 2 (SLC1A2, EAAT2, GLT1)
- excitatory amino acid transporter 3; Na+ dependent glutamate/aspartate transporter 3; excitatory amino-acid carrier 1; neuronal & epithelial glutamate transporter; solute carrier family 1 member 1 (SLC1A1, EAAC1, EAAT3)
- excitatory amino acid transporter 4; Na+ dependent glutamate/aspartate transporter; solute carrier family 1 member 6 (SLC1A6, EAAT4)
- excitatory amino acid transporter 5; retinal glutamate transporter; solute carrier family 1 member 7 (SLC1A7 EAAT5)
References
- ↑ Kanai Y, Smith CP, Hediger MA. A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 1993 Dec;7(15):1450-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7903261
- ↑ Pines G et al Cloning and expression of a rat brain L-glutamate transporter. Science 360:464 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1448170
- ↑ Kanai Y, Hediger MA. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 1992 Dec 3;360(6403):467-71. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1280334