excitatory amino acid transporter 3; Na+ dependent glutamate/aspartate transporter 3; excitatory amino-acid carrier 1; neuronal & epithelial glutamate transporter; solute carrier family 1 member 1 (SLC1A1, EAAC1, EAAT3)

Function

• transports L-glutamate & also L- & D-aspartate
• essential for terminating postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
• acts as a symporter by cotransporting Na+
• negatively regulated by ARL6IP5 (putative)
• neuronal glutamate/aspartate transporter
• interacts with ARL6IP5/PRAF3 (putative)

Structure

• glycosylated
• belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family

Compartment

membrane

Expression

• expressed in all tissues tested including:
  • liver, muscle, testis, ovary, retinoblastoma cell line, neurons & brain
• dense expression in substantia nigra, red nucleus, hippocampus & in cerebral cortical layers)

Pathology

• defects in SLC1A1 may be a cause of
• dicarboxylicamino aciduria

More general terms

• transmembrane 10 protein
• glutamate/aspartate transporter
• glycoprotein
• solute carrier family 1 (SLC1 SLC1A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6505
• OMIM: https://mirror.omim.org/entry/133550
• OMIM: https://mirror.omim.org/entry/222730
• UniProt: http://www.uniprot.org/uniprot/P43005.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6505