excitatory amino acid transporter 1; Na+ dependent glutamate/aspartate transporter 1; GLAST-1; solute carrier family 1 member 3 (SLC1A3, EAAT1, GLAST, GLAST1)

Function

• transports L-glutamate & also L- & D-aspartate
• essential for terminating postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
• acts as a symporter by cotransporting Na+
• may be astrocyte/glial glutamate/aspartate transporter in brain

Structure

• glycosylated
• belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family

Compartment

membrane

Expression

• highly expressed in cerebellum
• also found in frontal cortex, hippocampus & basal ganglia

Pathology

• defects in SLC1A3 are the cause of episodic ataxia type 6

More general terms

• transmembrane 6 protein
• glutamate/aspartate transporter
• solute carrier family 1 (SLC1 SLC1A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6507
• OMIM: https://mirror.omim.org/entry/600111
• UniProt: http://www.uniprot.org/uniprot/P43003.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6507