excitatory amino acid transporter 5; retinal glutamate transporter; solute carrier family 1 member 7 (SLC1A7 EAAT5)

Function

• transports L-glutamate
• L-glutamate uptake is Na+ & voltage-dependent & chloride-independent
• associated chloride conductance may participate in visual processing
• interacts with the PDZ domains of DLG4

Structure

• belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family

Compartment

membrane

Expression

• expressed primarily in retina
• detectable in liver, heart, muscle & brain

More general terms

• transmembrane 10 protein
• glutamate/aspartate transporter
• glycoprotein
• solute carrier family 1 (SLC1 SLC1A)

Database

• OMIM: https://mirror.omim.org/entry/604471
• UniProt: http://www.uniprot.org/uniprot/O00341.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6512