pleckstrin homology domain-containing family A member 2; PH domain-containing family A member 2; tandem PH domain-containing protein 2; TAPP-2 (PLEKHA2 TAPP2)

Function

• binds specifically to phosphatidylinositol-3,4-diphosphate (Ptdins(3,4)P2), but not to other phosphoinositides
• may recruit other proteins to the plasma membrane (putative)
• binds MPDZ & PTPN13 (putative)

Structure

contains 2 PH domains

Compartment

• cytoplasm (putative), cell membrane, nucleus
• locates to the plasma membrane after treatments that stimulate production of Ptdins(3,4)P2 (putative)

Expression

• highly expressed in heart, kidney, spleen & peripheral blood leukocytes
• detected at lower levels in brain, skeletal muscle, colon, thymus, liver, small intestine, placenta & lung

More general terms

• pleckstrin homology domain containing family A (PLEKHA)
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59339
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59339
• OMIM: https://mirror.omim.org/entry/607773
• UniProt: http://www.uniprot.org/uniprot/Q9HB19.html