Bromodomain-containing protein 7 (75 kDa bromodomain protein, protein CELTIX-1, BRD7, BP75, CELTIX1)

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Function

acts both as coactivator & as corepressor
may play a role in chromatin remodeling
activates Wnt signaling pathway
negatively regulates GSK3B (DVL1-dependent)
induces dephosphorylation of GSK3B at Y216
down-regulates TRIM24-mediated activation of transcriptional activation by AR (putative)
increases histone H3 acetylation at Lys-9 (H3K9ac)
binds to the ESR1 promoter
recruits BRCA1 & POU2F1 to the ESR1 promoter
coactivator for TP53-mediated activation of transcription of a set of target genes
required for TP53-mediated cell-cycle arrest in response to oncogene activation
promotes acetylation of TP53 at Lys-382, & thus promotes efficient recruitment of TP53 to target promoters
inhibits cell cycle progression from G1 phase to S phase
identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D & ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (putative)
interacts with TRIM24, PTPN13 & DVL1
interacts with PTPN13, DVL, IRF2, HNRPUL1
interacts with IRF2 & HNRPUL1
interacts (via N-terminus) with TP53. interacts (via C-terminus) with EP300. interacts with BRCA1
interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at Lys-14 (H3K14ac)
low affinity for histone H3 acetylated at Lys-9 (H3K9ac)
has highest affinity for histone H3 that is acetylated both at Lys-9 (H3K9ac) & at Lys-14 (H3K14ac) has very low affinity for non-acetylated histone H3
interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at Lys-8 (H3K8ac) (in vitro)

contains 1 bromo domain