SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1; SWI/SNF complex subunit SMARCC1; SWI/SNF complex 155 kD subunit; BRG1-associated factor 155; BAF155 (SMARCC1, BAF155)
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Function
- role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
- associated with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
- component of the npBAF complex & the nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic
- phosphorylated on undefined residues at the G2/M transition by ERK1 & other kinases; this may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein
- component of multiprotein chromatin-remodeling complexes:
- may stimulate the ATPase activity of the catalytic subunit of the complex (either SMARCA4 or SMARCA2)
- may also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 & SMARCA4
- the minimal complex composed of SMARCC1 & SMARCA4 seems to be able to associate with cyclin such as CCNE1 or transcription factors such as KLF1 or GATA1
- interacts with NR3C1 & SMARD1
Structure
- belongs to the SMARCC family
- contains 1 SANT domain
- contains 1 SWIRM domain
Compartment
Expression
More general terms
- SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily C
- BRG1 associated factor
- nuclear protein
- phosphoprotein
Component of
- SWI/SNF-A (BAF) chromatin remodeling complex
- npBAF complex (neural progenitors-specific chromatin remodeling complex)
- nBAF complex (neuron-specific chromatin remodeling complex)
- WINAC complex