SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; transcription activator BRG1; ATP-dependent helicase SMARCA4; SNF2-beta; protein BRG-1; mitotic growth & transcription activator; protein brahma homolog 1; BRG1-associated factor 190A; BAF190A (SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4)

Function

• transcriptional coactivator
• cooperates with nuclear hormone receptors to potentiate transcriptional activation
• component of the CREST-BRG1 complex
• component of the BAF complex
  • interacts directly with IKFZ1 in the BAF complex
• component of the BAF53 complex
• component of the npBAF complex & nBAF complex, neural stem/progenitor & post-mitotic chromatin remodeling complexes
  • SMARCA4/BAF190A may promote neural stem cell self-renewal/ proliferation by enhancing notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (putative)
• component of the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
• component of the BAF53, which preferentially acetylates histone H4 (and H2A) within nucleosomes
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with NR3C1, PGR, SMARD1, TOPBP1 & ZMIM2/ZIMP7
• interacts with (via the bromodomain) with TERT; the interaction regulates Wnt-mediated signaling
• interacts with PHF10/BAF45A

Structure

• belongs to the SNF2/RAD54 helicase family
• contains 1 bromo domain
• contains 1 helicase ATP-binding domain
• contains 1 helicase C-terminal domain
• contains 1 HSA domain

Compartment

nucleus

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A
• phosphoprotein

Component of

• CREST-BRG1 complex
• WINAC complex
• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)
• SWI/SNF-A (BAF) chromatin remodeling complex
• BAF53 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6597
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6597
• OMIM: https://mirror.omim.org/entry/603254
• UniProt: http://www.uniprot.org/uniprot/P51532.html