nBAF complex (neuron-specific chromatin remodeling complex)

Function

• chromatin remodeling
• during neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle & become committed to their adult state
• the transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF & nBAF complexes
• as neural progenitors exit mitosis & differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A & PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B & DPF1/BAF45B or DPF3/BAF45C subunits in nBAF complexes
• the nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth

Structure

• subunits: ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B & actin

More general terms

• SWI/SNF-A (BAF) chromatin remodeling complex

Additional terms

• npBAF complex (neural progenitors-specific chromatin remodeling complex)