SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2; SWI/SNF complex subunit SMARCC2; SWI/SNF complex 170 kD subunit; BRG1-associated factor 170; BAF170 (SMARCC2, BAF170)

Function

• role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
• can stimulate the ATPase activity of the catalytic subunit of these complexes
• may be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells
• associated with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
• component of the npBAF complex & the nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons
• component of multiprotein chromatin-remodeling complexes:
  • Swi/Snf-A complex (BAF complex)
  • Swi/Snf-B complex (PBAF complex)
  • Brm complex
  • Brg1(I) complex
  • WINAC complex
  • Brg1(II) complex
• may also interact with the SIN3A histone deacetylase transcription repressor complex in conjunction with SMARCA2 & SMARCA4

Structure

• belongs to the SMARCC family
• contains 1 SANT domain
• contains 1 SWIRM domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed

More general terms

• SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily C
• BRG1 associated factor
• nuclear protein
• phosphoprotein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex
• npBAF complex (neural progenitors-specific chromatin remodeling complex)
• nBAF complex (neuron-specific chromatin remodeling complex)
• WINAC complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6601
• OMIM: https://mirror.omim.org/entry/601734
• UniProt: http://www.uniprot.org/uniprot/Q8TAQ2.html