WINAC complex

Function

• chromatin-remodeling complex recruited by vitamin D receptor
• required for the ligand-bound vitamin D receptor mediated transrepression of the CYP27B1 gene

Structure

• subunits: SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A & TOP2B

More general terms

• molecular complex