AT-rich interactive domain-containing protein 1A; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF complex protein p270; B120; SWI-like protein; Osa homolog 1; hOSA1; hELD; BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A (ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1)
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Function
- role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
- binds DNA non-specifically
- associatEd with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor
- component of the BAF complex(SWI/SNF-A complex)
- component of npBAF complex) & nBAF complex, involved in a switch from a neural stem/progenitord to post-mitotic neurons
- component of SWI/SNF chromatin remodeling complexes
- phosphorylated upon DNA damage, probably by ATM or ATR
- component of the SWI/SNF-B complex (PBAF complex)
- component of the SWI/SNF Brm complex
- component of the SWI/SNF complex Brg1(I)
- component of the SWI/SNF complex Brg1(II)
- component of a SWI/SNF-like EPAFa complex
- component of a SWI/SNF-like complex containing ARID1A/BAF250A & ARID1B/BAF250B
- interacts through its C- terminus with SMARCA2/BRM/BAF190B & SMARCA4/BRG1/BAF190A
- interacts with SMARCC1/BAF155
Structure
contains 1 ARID domain
Compartment
Alternative splicing
named isoforms=3
Expression
- highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, & peripheral blood leukocytes
expressed at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, & pancreas
More general terms
- SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily F
- DNA-binding protein
- nuclear protein
- phosphoprotein