AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B, Osa homolog 2, hOsa2, p250R, BRG1-binding protein hELD/OSA1, BRG1-associated factor 250b, BAF250B, ARID1B, DAN15, KIAA1235, OSA2)

Function

• role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology)
• binds DNA non-specifically
• component of SWI/SNF chromatin remodeling complexes
  • SWI/SNF-A complex
  • SWI/SNF-B complex
  • SWI/SNF-like EPAFb complex
• interacts through its C- terminus with SMARCA2& SMARCA4
• interacts with SMARCC1

Structure

contains 1 ARID domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed
• high levels in heart, skeletal muscle & kidney

Notes

uncertain whether Met-1 or Met-59 is the initiator

More general terms

• AT-rich interactive domain-containing protein

Component of

• SWI/SNF-A (BAF) chromatin remodeling complex
• SWI/SNF-B (PBAF) chromatin remodeling complex
• SWI/SNF-like EPAFb chromatin remodeling complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NFD5.html